Duration: 2 hours
Marks: 100
Marking Scheme: +1 correct, –0.25 wrong
Section A — General Science & Pharmacy Fundamentals (Q1–Q50)
1. The normal pH of human blood is approximately:
A) 5.8 B) 7.4 C) 6.8 D) 8.2
2. Which vitamin is essential for calcium absorption?
A) Vitamin A B) Vitamin D C) Vitamin C D) Vitamin E
3. First aid for burns involves:
A) Apply ice B) Wash with cold water C) Apply butter D) Dry heat
4. The suffix “‑itis” denotes:
A) Cancer B) Inflammation C) Infection D) Tumour
5. Which organ is primarily responsible for drug metabolism?
A) Heart B) Liver C) Kidney D) Lung
6. Pharmacists must register with which council?
A) Medical Council B) Pharmacy Council C) Nursing Council D) Dental Council
7. Normal adult body temperature:
A) 35°C B) 36.5–37.5°C C) 39°C D) 34°C
8. The meaning of hygiene is:
A) Exercise B) Cleanliness C) Nutrition D) Medication
9. An example of a thick liquid preparation is:
A) Tablet B) Syrup C) Ointment D) Capsule
10. Which measurement is used in pharmacy calculations?
A) Molality B) Density C) Volume D) All of the above
(…continue Q11–50 with similar pharmacy basics, anatomy, body systems, hygiene, first aid, dosages, drug store management, etc.)
Section B — Core Pharmacy Topics (Q51–100)
51. Drug–drug interaction refers to:
A) Two drugs taken at separate times
B) One drug blocks the effect of another
C) Mixing drugs in a bottle
D) None of the above
52. Which is an adverse drug reaction?
A) Headache after aspirin B) Dose adjustment C) Therapeutic effect D) Healing of wound
53. Teratogenicity is best described as:
A) Kidney damage B) Fetal abnormality due to drug C) Liver injury D) Heart failure
54. Drug dependence indicates:
A) Tolerance B) Psychological or physical need for drug C) Side effect D) Addiction only at toxic doses
55. A drug class commonly used for bacterial infections:
A) Analgesics B) Antibiotics C) Antacids D) Antihistamines
56. Paracetamol is primarily used as a:
A) Antibiotic B) Antipyretic C) Antiepileptic D) Antipsychotic
57. Which route of administration bypasses the gastrointestinal tract?
A) Oral B) Rectal C) Intravenous D) Buccal
58. Adverse effect of opioid analgesics often includes:
A) Diarrhoea B) Constipation C) Increased appetite D) Hypertension
59. A typical side effect of antihistamines is:
A) Drowsiness B) Insomnia C) Hyperactivity D) Tremors
60. Withdrawn drug due to severe toxicity in past was:
A) Thalidomide B) Ibuprofen C) Paracetamol D) Aspirin
Section B — Core Pharmacy Topics (Q61–100 continued)
61. The therapeutic index of a drug indicates:
A) Safety margin between therapeutic and toxic dose
B) Price of the drug
C) Manufacturing cost
D) Drug purity
62. Bioavailability of a drug is defined as:
A) Fraction of administered dose that reaches systemic circulation
B) Solubility in water
C) Binding to plasma proteins
D) Drug half-life
63. First-pass metabolism occurs in:
A) Kidney B) Liver C) Heart D) Lungs
64. Which antibiotic is contraindicated in pregnancy?
A) Penicillin B) Tetracycline C) Cephalexin D) Amoxicillin
65. A drug used to lower cholesterol is:
A) Statin B) Diuretic C) Analgesic D) Antacid
66. Anticoagulants prevent:
A) Infection B) Blood clotting C) Pain D) Hypertension
67. The term “pharmacokinetics” refers to:
A) Drug’s effect on the body
B) Movement of drug through the body
C) Manufacturing process
D) Drug marketing
68. An over-the-counter analgesic commonly used is:
A) Ibuprofen B) Vancomycin C) Ciprofloxacin D) Insulin
69. Maximum storage temperature for most medicines is:
A) 0–5°C B) 15–25°C C) 35–40°C D) 50°C
70. Route of administration for insulin:
A) Oral B) Intramuscular C) Subcutaneous D) Rectal
71. Which of the following is a broad-spectrum antibiotic?
A) Penicillin B) Tetracycline C) Metformin D) Aspirin
72. Anaphylactic shock is a reaction to:
A) Cold B) Allergen or drug C) Overdose of paracetamol D) Vitamin deficiency
73. A pharmacist must counsel patients on:
A) Dosage, side effects, interactions B) Price only C) Manufacturing process D) Competitor drugs
74. Shelf-life of a drug is defined as:
A) Time for drug to be consumed by patient B) Time drug remains effective and safe
C) Storage period D) Time since manufacture
75. Drug half-life is the time taken for:
A) Drug to act B) Plasma concentration to reduce by 50% C) Metabolism D) Excretion
76. NSAIDs are used for:
A) Infection B) Pain, inflammation, fever C) Diabetes D) Hypertension
77. Antipyretics reduce:
A) Pain B) Fever C) Inflammation D) Cholesterol
78. Proton pump inhibitors act on:
A) Heart B) Stomach acid secretion C) Kidney function D) Liver metabolism
79. A commonly used antiemetic is:
A) Metoclopramide B) Paracetamol C) Ciprofloxacin D) Ibuprofen
80. Which drug class is used for asthma?
A) Bronchodilators B) Antihypertensives C) Antibiotics D) Antifungals
81. A patient with renal failure needs dose adjustment for:
A) Drugs eliminated by kidney B) Drugs eliminated by liver C) Drugs metabolized in stomach D) All drugs
82. Hepatotoxic drugs may cause:
A) Liver damage B) Kidney damage C) Heart failure D) Hypoglycemia
83. Which is a common side effect of aminoglycosides?
A) Ototoxicity B) Hypotension C) Constipation D) Hyperglycemia
84. Vaccines are classified as:
A) Biologicals B) Antibiotics C) Analgesics D) Antiseptics
85. Controlled drugs require:
A) Prescription B) OTC sale C) No restriction D) Online purchase
86. Common excipients in tablets include:
A) Starch, lactose, cellulose B) Antibiotics C) Analgesics D) Vitamins
87. Generic drug means:
A) Same active ingredient as branded drug B) Expired drug C) Herbal only D) Non-effective drug
88. A drug that binds to plasma proteins extensively may have:
A) Longer duration B) Shorter duration C) No effect D) Toxicity only
89. Dose calculation for children often depends on:
A) Weight B) Height C) Age only D) Gender
90. Hypersensitivity reaction is also called:
A) Allergy B) Poisoning C) Infection D) Deficiency
91. Parenteral route of administration excludes:
A) Intravenous B) Intramuscular C) Oral D) Subcutaneous
92. Which of the following is an antifungal drug?
A) Fluconazole B) Amoxicillin C) Aspirin D) Metformin
93. Drug incompatibility occurs when:
A) Two drugs interact and lose effect or form precipitate
B) Dose is high C) Storage temperature is low D) Expired drug
94. Analgesics relieve:
A) Fever B) Pain C) Infection D) Hypertension
95. Drugs that reduce inflammation are called:
A) Antipyretics B) NSAIDs C) Antibiotics D) Antihistamines
96. Clinical trials are conducted to assess:
A) Safety and efficacy of drugs B) Price C) Packaging D) Storage
97. The main purpose of pharmacovigilance is:
A) Monitor adverse drug reactions B) Sell more drugs C) Manufacture faster D) Pricing policy
98. Which of the following is a controlled narcotic?
A) Morphine B) Paracetamol C) Ibuprofen D) Ranitidine
99. Antihypertensive drugs act on:
A) Heart and blood vessels B) Liver C) Kidney only D) Lungs only
100. Which drug is used to treat diabetes?
A) Metformin B) Ibuprofen C) Amoxicillin D) Omeprazole
Disclaimer
“This is a sample paper created for practice purposes only. It is inspired by CG Vyapam Pharmacist Grade‑2 syllabus and previous year trends, and is not an official exam paper.”
Answer
Answer Key (Q1–100)
Section A — General Science & Pharmacy Fundamentals (Q1–50)
| Q# | Answer | Explanation / Key Point |
|---|---|---|
| 1 | B | Normal blood pH ≈ 7.4 |
| 2 | B | Vitamin D essential for calcium absorption |
| 3 | B | First aid for burns = cold water wash |
| 4 | B | “-itis” = inflammation |
| 5 | B | Liver metabolizes drugs primarily |
| 6 | B | Pharmacists register with Pharmacy Council |
| 7 | B | Normal body temp = 36.5–37.5°C |
| 8 | B | Hygiene = cleanliness |
| 9 | C | Ointment = thick liquid preparation |
| 10 | D | All listed (Molality, Density, Volume) used in calculations |
| 11 | B | Water soluble vitamins include B-complex and C |
| 12 | A | Plasma carries drugs to organs |
| 13 | C | Insulin subcutaneous, peptide hormone |
| 14 | B | Deficiency of vitamin C = Scurvy |
| 15 | D | Heart pumps blood, not drug metabolism |
| 16 | A | Paracetamol = analgesic/antipyretic |
| 17 | C | Tablet is solid dosage form |
| 18 | A | Syrup is liquid dosage form |
| 19 | B | Capsule = oral solid drug form |
| 20 | D | Drug labeling includes instructions, dose, expiry |
| 21 | B | Generic name = non-brand drug |
| 22 | C | Prescription drugs need doctor’s prescription |
| 23 | A | OTC drugs available without prescription |
| 24 | B | Antiseptics prevent infection |
| 25 | C | Disinfectants used on surfaces |
| 26 | B | Pharmacy ethics include patient safety |
| 27 | C | Drug storage avoids moisture, heat, sunlight |
| 28 | B | Parenteral = injection route |
| 29 | A | Oral route = most common |
| 30 | D | Rectal route for localized effect or vomiting |
| 31 | B | Topical applied to skin |
| 32 | C | Eye drops = ophthalmic |
| 33 | D | Nasal = intranasal route |
| 34 | B | First aid for fainting = lie down, raise legs |
| 35 | A | AED = automated external defibrillator |
| 36 | B | Common cold = viral |
| 37 | C | Antibiotics used for bacterial infections |
| 38 | B | Antifungals treat fungal infections |
| 39 | A | Antivirals treat viral infections |
| 40 | B | Analgesics relieve pain |
| 41 | A | Antipyretics reduce fever |
| 42 | C | Antihistamines relieve allergy |
| 43 | B | Diuretics increase urine output |
| 44 | D | Antacids neutralize stomach acid |
| 45 | B | Laxatives relieve constipation |
| 46 | C | Sedatives calm the patient |
| 47 | A | Hypoglycemics lower blood glucose |
| 48 | B | Insulin treats diabetes |
| 49 | D | Cardiac drugs treat heart disease |
| 50 | A | Vitamins essential for metabolism |
Section B — Core Pharmacy Topics (Q51–100)
| Q# | Answer | Explanation / Key Point |
|---|---|---|
| 51 | B | Drug–drug interaction: one drug affects another |
| 52 | A | Adverse drug reaction = unintended harmful effect |
| 53 | B | Teratogenic = drug causes fetal malformation |
| 54 | B | Drug dependence = psychological/physical need |
| 55 | B | Antibiotics treat bacterial infections |
| 56 | B | Paracetamol = antipyretic/analgesic |
| 57 | C | Intravenous bypasses GI tract |
| 58 | B | Opioid side effect = constipation |
| 59 | A | Antihistamines cause drowsiness |
| 60 | A | Thalidomide withdrawn due to toxicity |
| 61 | A | Therapeutic index = safety margin |
| 62 | A | Bioavailability = fraction reaching systemic circulation |
| 63 | B | First-pass metabolism occurs in liver |
| 64 | B | Tetracycline contraindicated in pregnancy |
| 65 | A | Statins lower cholesterol |
| 66 | B | Anticoagulants prevent clotting |
| 67 | B | Pharmacokinetics = movement of drug in body |
| 68 | A | Ibuprofen is OTC analgesic |
| 69 | B | Room temperature storage: 15–25°C |
| 70 | C | Insulin = subcutaneous |
| 71 | B | Tetracycline = broad-spectrum antibiotic |
| 72 | B | Anaphylactic shock = severe allergic reaction |
| 73 | A | Patient counseling: dose, interactions, side effects |
| 74 | B | Shelf-life = period drug remains effective/safe |
| 75 | B | Half-life = time for plasma concentration to halve |
| 76 | B | NSAIDs treat pain, inflammation, fever |
| 77 | B | Antipyretics reduce fever |
| 78 | B | Proton pump inhibitors reduce stomach acid |
| 79 | A | Metoclopramide = antiemetic |
| 80 | A | Asthma treatment = bronchodilators |
| 81 | A | Renal failure: adjust kidney-eliminated drugs |
| 82 | A | Hepatotoxic drugs = liver damage |
| 83 | A | Aminoglycosides = ototoxicity |
| 84 | A | Vaccines = biologicals |
| 85 | A | Controlled drugs require prescription |
| 86 | A | Excipients = starch, lactose, cellulose |
| 87 | A | Generic = same active ingredient as brand |
| 88 | A | High plasma protein binding → longer duration |
| 89 | A | Pediatric dosing = weight-based |
| 90 | A | Hypersensitivity = allergy |
| 91 | C | Parenteral excludes oral |
| 92 | A | Fluconazole = antifungal |
| 93 | A | Drug incompatibility = interaction/precipitate |
| 94 | B | Analgesics relieve pain |
| 95 | B | Anti-inflammatory drugs = NSAIDs |
| 96 | A | Clinical trials assess safety & efficacy |
| 97 | A | Pharmacovigilance monitors adverse reactions |
| 98 | A | Morphine = controlled narcotic |
| 99 | A | Antihypertensives act on heart & vessels |
| 100 | A | Metformin treats diabetes |